Chemistry Seminar Series: Michael Trakselis

The Department of Chemistry and Biochemistry presents "Dynamic Regulation of Replisome Progression" with Michael Trakselis, professor at Baylor University. Hosted by Sean Johnson. Projects in the Trakselis laboratory center on understanding the molecular mechanisms of DNA replication and repair and exploiting this knowledge for cancer therapeutics, biotechnology, and nanoscale applications. The lab utilizes a model archaeal DNA replication system which shares significant homology to that of higher eukaryotes but is amenable to in vitro biochemistry experiments. This allows them to draw parallels between different domains of life using simpler replication systems. Additionally, they utilize cellular biology approaches in human cells to investigate the roles of various enzymes in double strand break repair. In this vain, they utilize molecular biology, biochemistry, genetics, cell biology and biophysical methods to probe this area of research.